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+This family accommodates just one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was [discovered](https://gitlab.fuxicarbon.com/jonis307977220/solicitor2009/wiki/10+Suggestions+When+Shopping+for+And+Promoting+A+Residence) to methylate, moreover histone, a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and elements of the TATA binding protein (TBP) complex, TBP-related factors TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-Ok (target lysine is bold), can also be recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of eradicating the methyl mark on most of those substrates 17 , ninety four Due to this fact KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of both histone and non-histone proteins.
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